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Fam Cancer. 2017 Jan;16(1):143-151. doi: 10.1007/s10689-016-9930-4.

Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance.

Author information

1
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
2
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, Amsterdam, The Netherlands.
3
Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.
4
Department of Medical Psychology, Academic Medical Center, Amsterdam, The Netherlands.
5
Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
6
Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
7
Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.
8
Department of Clinical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
9
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
10
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, Amsterdam, The Netherlands. e.bleiker@nki.nl.
11
Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands. e.bleiker@nki.nl.

Abstract

It is important to adequately and timely identify individuals with cancer worries amongst participants in a pancreatic ductal adenocarcinoma (PDAC) surveillance program, because they could benefit from psychosocial support to decrease distress. Therefore, the aim of this study was to assess both psychosocial and clinical factors associated with cancer worries. High-risk individuals participating in PDAC-surveillance were invited to annually complete a cancer worry scale (CWS) questionnaire which was sent after counseling by the clinical geneticist (T0), after intake for participation in PDAC-surveillance (T1), and then annually after every MRI and endoscopic ultrasonography (EUS) (T2 and further). Analyses were performed to identify factors associated with cancer worries in the second year of surveillance (T3). We found a significant intra-individual decrease in cancer worries (β = -0.84, P < 0.001), nevertheless, 33 % of individuals had a CWS-score ≥14 at T3. We found one factor significantly associated with cancer worries at T3: having a family member affected by PDAC <50 years of age (β = 0.22, P = 0.03). The detection of a cystic lesion, a shortened surveillance interval, or undergoing pancreatic surgery did not lead to more cancer worries (P = 0.163, P = 0.33, and P = 0.53, respectively). In conclusion, this study identified 'a family history of PDAC <50 years of age' as the only predictor of cancer worries experienced after 2 years of surveillance in individuals at high risk of developing PDAC. This knowledge could help clinicians to timely identify individuals 'at risk' for high levels of cancer worries who would likely benefit from psychosocial support.

KEYWORDS:

Cancer worries; High-risk individuals; Pancreatic cancer; Predictive factors; Psychosocial burden; Surveillance

PMID:
27629874
PMCID:
PMC5243886
DOI:
10.1007/s10689-016-9930-4
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

The authors declare that they have no conflict of interest. Ethical approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent Informed consent was obtained from all individual participants included in the study. Research involving human participants The Ethical Committee of all participating centers approved the study protocol and the study was conducted in accordance with the Declaration of Helsinki. All participants gave written informed consent prior to the performance of any study-related investigations.

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