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Nature. 2016 Sep 15;537(7620):328-38. doi: 10.1038/nature19947.

Proteome complexity and the forces that drive proteome imbalance.

Author information

1
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
2
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.

Abstract

The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic needs of the cell. It is therefore crucial that the protein flux of the cell remains in balance to ensure proper cell function. Genetic alterations that range from chromosome imbalance to oncogene activation can affect the speed, fidelity and capacity of protein biogenesis and degradation systems, which often results in proteome imbalance. An improved understanding of the causes and consequences of proteome imbalance is helping to reveal how these systems can be targeted to treat diseases such as cancer.

PMID:
27629639
PMCID:
PMC5204264
DOI:
10.1038/nature19947
[Indexed for MEDLINE]
Free PMC Article

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