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J Perinatol. 2016 Dec;36(12):1039-1044. doi: 10.1038/jp.2016.150. Epub 2016 Sep 15.

Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh.

Author information

1
Division of Medicine Critical Care, Boston Children's Hospital, Boston, MA, USA.
2
Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
3
Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
4
Department of Pathology, Boston Children's Hospital, Boston, MA, USA.
5
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Abstract

OBJECTIVE:

To estimate the association between chorioamnionitis, maternal risk factors and birth outcomes.

STUDY DESIGN:

A cross-sectional study of 600 pregnant women was conducted at a maternity center in Dhaka from January to October 2011. Outcomes included histologic, microbiologic and clinical chorioamnionitis. Log-binomial models assessed the association between risk factors and histologic chorioamnionitis (HC).

RESULTS:

Of the 552 women with placental specimens, 70 (12.7%) were classified with HC: 46 (65.7%) with and 24 (34.3%) without fetal involvement. HC was associated with non-physician care (relative risk [RR] 2.04, 95% confidence interval [CI] 1.04 to 4.00), home slab or hanging latrine (RR 1.69, 95% CI 1.10 to 2.62), and lack of tetanus toxoid (RR 1.80, 95% CI 1.03 to 3.14). Women with fever (RR 2.30, 95% CI 1.18 to 4.50) or discolored amniotic fluid (RR 1.74, 95% CI 1.08 to 2.81) had a higher risk of HC. Microbiologic and clinical chorioamnionitis were unreliable HC measures.

CONCLUSION:

Prevalence of HC is high; many cases are not captured by clinical diagnosis or microbiologic cultures.

PMID:
27629373
DOI:
10.1038/jp.2016.150
[Indexed for MEDLINE]

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