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J Autism Dev Disord. 2016 Dec;46(12):3830-3837.

Brief Report: Autism Symptoms in Infants with Fragile X Syndrome.

Author information

1
Department of Psychology, University of South Carolina, Columbia, SC, USA. jane.roberts@sc.edu.
2
Department of Psychological Sciences, Purdue University, West Lafayette, IN, USA.
3
Waisman Center, University of Wisconson, Madison, WI, USA.
4
Department of Psychology, University of South Carolina, Columbia, SC, USA.

Abstract

Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50-75 % of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53 % of 12-month infants with FXS fall in the "at risk" category compared to 17 and 6 % for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS.

KEYWORDS:

Autism; Autism Observation Scale for Infants; Fragile X; Infants

PMID:
27628938
PMCID:
PMC5112110
DOI:
10.1007/s10803-016-2903-5
[Indexed for MEDLINE]
Free PMC Article

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