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Hum Brain Mapp. 2017 Jan;38(1):396-413. doi: 10.1002/hbm.23368. Epub 2016 Sep 15.

A Meta-analysis on the neural basis of planning: Activation likelihood estimation of functional brain imaging results in the Tower of London task.

Nitschke K1,2,3,4,5, Köstering L1,2,3,4,6, Finkel L1,7, Weiller C1,2,3,4, Kaller CP1,2,3,4.

Author information

1
Department of Neurology, Medical Center - University of Freiburg, Freiburg, Germany.
2
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
3
Freiburg Brain Imaging Center University of Freiburg, Freiburg, Germany.
4
BrainLinks-BrainTools Cluster of Excellence University of Freiburg, Freiburg, Germany.
5
Biological and Personality Psychology, Department of Psychology, University of Freiburg, Freiburg, Germany.
6
Department of Neuroradiology, Medical Center - University of Freiburg, Freiburg, Germany.
7
Motor Cognition Group, Department of Psychology, University of Konstanz, Konstanz, Germany.

Abstract

The ability to mentally design and evaluate series of future actions has often been studied in terms of planning abilities, commonly using well-structured laboratory tasks like the Tower of London (ToL). Despite a wealth of studies, findings on the specific localization of planning processes within prefrontal cortex (PFC) and on the hemispheric lateralization are equivocal. Here, we address this issue by integrating evidence from two different sources of data: First, we provide a systematic overview of the existing lesion data on planning in the ToL (10 studies, 211 patients) which does not indicate any evidence for a general lateralization of planning processes in (pre)frontal cortex. Second, we report a quantitative meta-analysis with activation likelihood estimation based on 31 functional neuroimaging datasets on the ToL. Separate meta-analyses of the activation patterns reported for Overall Planning (537 participants) and for Planning Complexity (182 participants) congruently show bilateral contributions of mid-dorsolateral PFC, frontal eye fields, supplementary motor area, precuneus, caudate, anterior insula, and inferior parietal cortex in addition to a left-lateralized involvement of rostrolateral PFC. In contrast to previous attributions of planning-related brain activity to the entire dorsolateral prefrontal cortex (dlPFC) and either its left or right homolog derived from single studies on the ToL, the present meta-analyses stress the pivotal role specifically of the mid-dorsolateral part of PFC (mid-dlPFC), presumably corresponding to Brodmann Areas 46 and 9/46, and strongly argue for a bilateral rather than lateralized involvement of the dlPFC in planning in the ToL. Hum Brain Mapp 38:396-413, 2017.

KEYWORDS:

Tower of London Task; activation likelihood estimation; functional neuroimaging; lesion studies; meta-analysis; planning; prefrontal cortex

PMID:
27627877
DOI:
10.1002/hbm.23368
[Indexed for MEDLINE]

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