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GMS Ophthalmol Cases. 2016 Apr 4;6:Doc05. doi: 10.3205/oc000042. eCollection 2016.

Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals.

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Division of Ophthalmology, University Hospitals KU Leuven, Leuven, Belgium.
Division Liver and Biliopancreatic Disorders, University Hospitals KU Leuven, Leuven, Belgium.


We report a patient with a bilateral optic anterior ischemic neuropathy as an extrahepatic complication of a chronic hepatitis C (HCV) infection. The patient presented with a bilateral visual acuity loss and bilateral optic disc oedema. The optic neuropathy was associated with a sudden increase in the viral HCV load after a recent liver transplantation. The stop of the calcineurin inhibitor had no effect on the course of the optic neuropathy. Visual improvement and normalization of HCV viraemia occurred after treatment with sofosbuvir and daclatasvir, which are direct acting antivirals.


daclatasvir; hepatitis C; non arteritic ischemic optic neuropathy; sofosbuvir

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