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Curr Biol. 2016 Sep 12;26(17):R806-9. doi: 10.1016/j.cub.2016.07.060.

Glucose Metabolism: A Sweet Relief of Alzheimer's Disease.

Author information

1
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
2
Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: chetz@med.uchile.cl.

Abstract

Patients and individuals at risk for Alzheimer's disease show reduced glucose metabolism in the brain. A new study takes advantage of a fly model of Alzheimer's disease to demonstrate that enhancing glucose uptake in neurons has strong neuroprotective effects involving improved proteostasis.

PMID:
27623263
DOI:
10.1016/j.cub.2016.07.060
[Indexed for MEDLINE]
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