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PLoS One. 2016 Sep 13;11(9):e0162254. doi: 10.1371/journal.pone.0162254. eCollection 2016.

Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson's Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study.

Author information

1
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
2
Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
3
Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
4
Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
5
Department of Biostatistics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
6
Department of Neurology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, Republic of Korea.
7
Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
8
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
9
Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
10
Department of Neurology, College of Medicine, Inje University, Ilsan-Paik Hospital, Ilsan, Republic of Korea.
11
Department of Neurology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
12
Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
13
Department of Neurology, National Health, Insurance Corporation Ilsan Hospital, Ilsan, Republic of Korea.
14
Department of Neurology, Inje University, Busan Paik Hospital, Busan, Republic of Korea.
15
Department of Neurology, Chonnam National University Medical School, Gwangju, Republic of Korea.
16
Department of Neurology, Presbyterian Medical Center, Jeonju, Republic of Korea.
17
Department of Neurology, College of Medicine, Inje University Seoul Paik Hospital, Seoul, Republic of Korea.
18
Department of Neurology, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
19
Department of Neurology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
20
Department of Neurology, CHA University College of Medicine, Bundang, Republic of Korea.
21
Department of Neurology, Dong-A University College of Medicine, Busan, Republic of Korea.
22
Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
23
Department of Neurology, Seoul National University Boramae Hospital, Seoul, Republic of Korea.
24
Department of Neurology, College of Medicine, Chungbuk National University Hospital, Jeonju, Republic of Korea.
25
Department of Neurology, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic of Korea.
26
Department of Neurology, Seoul National University Bundang Hospital, Bundang, Republic of Korea.
27
Department of Neurology, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea.
28
Department of Neurology, Kosin University College of Medicine, Busan, Republic of Korea.
29
Department of Neurology, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Republic of Korea.
30
Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
31
Department of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea.
32
Department of Neurology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
33
Department of Neurology, Jeju National University Hospital, Jeju, Republic of Korea.
34
Department of Neurology, Konyang University Hospital, Daejeon, Republic of Korea.
35
Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.
36
Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
37
Department of Neurology, College of Medicine, the Catholic University of Korea, Incheon, Republic of Korea.
38
Department of Neurology, Yonsei University, College of Medicine, Seoul, Republic of Korea.
39
Department of Neurology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
40
Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.
41
Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
42
Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.

Abstract

Despite the clinical impact of non-motor symptoms (NMS) in Parkinson's disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed. We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristic NMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristic NMS associated with NTD subtype in PD patients.

PMID:
27622838
PMCID:
PMC5021347
DOI:
10.1371/journal.pone.0162254
[Indexed for MEDLINE]
Free PMC Article

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