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Nucleic Acids Res. 1989 Jul 25;17(14):5477-88.

Identification of two transactivation domains in the mouse oestrogen receptor.

Author information

1
Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, London, UK.

Abstract

We have identified two discrete transactivation domains within the mouse oestrogen receptor whose relative activities vary according to the target promoter. One domain lies within the N-terminal region and is active in the absence of oestradiol. The second domain is contained within the C-terminal portion of the protein and depends upon oestrogen binding for its activity. The location and oestrogen dependence of this domain has been confirmed using chimaeric receptors containing the Lex A DNA binding domain. Although transactivation by the C-terminal domain is dependent upon ligand binding the analysis of receptor deletion mutants has demonstrated that these two functions are not entirely coincident.

PMID:
2762146
PMCID:
PMC318171
DOI:
10.1093/nar/17.14.5477
[Indexed for MEDLINE]
Free PMC Article

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