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Andrologia. 2017 Sep;49(7). doi: 10.1111/and.12697. Epub 2016 Sep 13.

Protective role of Aloe vera against X-ray induced testicular dysfunction.

Author information

1
Department of Biophysics, Panjab University, Chandigarh, India.
2
Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.

Abstract

The present investigation was carried out to evaluate the possible radioprotective potential of an Aloe vera extract against whole-body X-ray irradiation-induced testicular alterations in mice. Male balb/c mice were divided into four groups: control, A. vera, X-ray and A. vera pre-treated + X-ray irradiated. Histopathological examination revealed significant structural alterations in testes after X-ray exposure, which was also associated with the presence of apoptotic cells as assessed by TUNEL assay. X-ray irradiation resulted in elevation in the levels of reactive oxygen species, lipid peroxidation, a reduction in glutathione concentration and enhanced activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, catalase, superoxide dismutase and glutathione-S-transferase. Sperm count/motility and testosterone levels were significantly decreased in the irradiated group. Irradiated animals pre-treated with A. vera extract revealed an improvement in antioxidant status, inhibition of lipid peroxides, apoptotic cell formation and enhanced testicular parameters when compared to the X-ray-exposed group. These findings suggest that A. vera extract could ameliorate X-ray-induced damage due to its free radical scavenging properties and its potential to boost cellular antioxidant defence machinery.

KEYWORDS:

Aloe vera ; LDH ; LPO ; X-ray; antioxidant enzymes; apoptosis

PMID:
27620003
DOI:
10.1111/and.12697
[Indexed for MEDLINE]

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