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J Nutr Biochem. 2016 Nov;37:60-66. doi: 10.1016/j.jnutbio.2016.07.009. Epub 2016 Aug 4.

Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice.

Author information

1
Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA.
2
Department of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA.
3
Department of Food Science, The Pennsylvania State University, University Park, PA 16802, USA; The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: jdl134@psu.edu.

Abstract

Cranberry (Vaccinium macrocarpon) consumption has been associated with health beneficial effects. Nonalcoholic fatty liver disease (NAFLD) is a comorbidity of obesity. In the present study, we investigated the effect of a polyphenol-rich cranberry extract (CBE) on hepatic inflammation in high fat (HF)-fed obese C57BL/6J mice. Following dietary treatment with 0.8% CBE for 10 weeks, we observed no change in body weight or visceral fat mass in CBE-supplemented mice compared to HF-fed control mice. We did observe a significant decrease in plasma alanine aminotransferase (31%) and histological severity of NAFLD (33% decrease in area of involvement, 29% decrease in lipid droplet size) compared to HF-fed controls. Hepatic protein levels of tumor necrosis factor α and C-C chemokine ligand 2 were reduced by 28% and 19%, respectively, following CBE supplementation. CBE significantly decreased hepatic mRNA levels of toll-like receptor 4 (TLR4, 63%) and nuclear factor κB (NFκB, 24%), as well as a number of genes related to the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 inflammasome. In conclusion, CBE reduced NAFLD and hepatic inflammation in HF-fed obese C57BL/6J mice. These effects appear to be related to mitigation of TLR4-NFκB related signaling; however, further studies into the underlying mechanisms of these hepatoprotective effects are needed.

KEYWORDS:

Cranberry; Inflammation; Nonalcoholic fatty liver disease; Polyphenols; Vaccinium macrocarpon

PMID:
27619543
PMCID:
PMC5228292
DOI:
10.1016/j.jnutbio.2016.07.009
[Indexed for MEDLINE]
Free PMC Article

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