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Oncogene. 2017 Mar;36(11):1461-1473. doi: 10.1038/onc.2016.304. Epub 2016 Sep 12.

Wnt signaling in cancer.

Author information

1
German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg University, Department Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg, Germany.
2
Heidelberg University, Department of Internal Medicine II, Medical Faculty Mannheim, Mannheim, Germany.
3
German Cancer Consortium (DKTK), Heidelberg, Germany.

Abstract

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.

PMID:
27617575
PMCID:
PMC5357762
DOI:
10.1038/onc.2016.304
[Indexed for MEDLINE]
Free PMC Article

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