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J Ginseng Res. 2016 Jul;40(3):203-10. doi: 10.1016/j.jgr.2015.07.006. Epub 2015 Aug 4.

Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease.

Author information

1
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
2
Department of Biomedical Science, Hallym University College of Medicine, Chuncheon, Korea.
3
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea; Department of Medicine, Columbia University, New York, NY, USA.
4
College of Agriculture and Life Science, Kangwon National University, Chuncheon, Korea.

Abstract

BACKGROUND:

Korean Red Ginseng (KRG) is a well-known natural product with anticarcinogenic and antioxidant effects. We evaluated the antifatigue effect of KRG in patients with nonalcoholic fatty liver disease (NAFLD).

METHODS:

Eighty patients with NAFLD were prospectively randomized to receive 3 wk of KRG or placebo in addition to counseling on healthy eating and regular exercise. Liver function test, proinflammatory cytokines, adiponectin, antioxidant activity, and fatigue score were measured and compared according to the body mass index between the KRG and placebo groups.

RESULTS:

The liver function tests were significantly improved after 3 wk of treatment in both groups. The mean levels (at baseline and after treatment) of tumor necrosis factor-α were 108.0 pg/mL ± 54.8 pg/mL and 92.7 pg/mL ± 39.0 pg/mL (p = 0.018) in the KRG group and 123.1 pg/mL ± 42.1 pg/mL and 127.5 pg/mL ± 62.2 pg/mL (p = 0.694) in the placebo group, respectively. There was a significant difference in change of adiponectin levels between the KRG (7,751.2 pg/mL ± 3,108.1 pg/mL and 8,197.3 pg/mL ± 2,714.5 pg/mL) and placebo groups (7,711.6 pg/mL ± 3,041.3 pg/mL and 7,286.1 pg/mL ± 5,188.7 pg/mL, p = 0.027). In patients with overweight, the fatigue score was significantly decreased in the KRG group (35.0 ± 13.2 and 24.5 ± 8.9, p = 0.019).

CONCLUSION:

Our results show that KRG might be effective in reducing proinflammatory cytokine and fatigue in overweight patients with NAFLD, in addition to improvements in adiponectin levels.

KEYWORDS:

Panax ginseng; adiponectin; chronic hepatitis; fatty liver

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