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Int J Biol Macromol. 2016 Dec;93(Pt A):904-912. doi: 10.1016/j.ijbiomac.2016.09.029. Epub 2016 Sep 9.

Effects of Ganoderma lucidum polysaccharides on chronic pancreatitis and intestinal microbiota in mice.

Author information

1
College of Resources and Environmental Science, Northeast Agricultural University, Harbin 150030, PR China.
2
Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
3
College of Resources and Environmental Science, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: juanjuan4050234@163.com.

Abstract

This study manifested the effects of polysaccharides from Ganoderma lucidum strain S3 (GLP S3) on chronic pancreatitis (CP) therapy and intestinal microbiota modulation in mice induced by diethyldithiocarbamate (DDC). The GLPS3 was prepared from cultured mycelium and markedly alleviated the pancreatitis in mice through decreasing lipase, AMS, IFN-γ and TNF-α level as well as increasing SOD and total antioxidant activity. Furthermore, high throughput sequencing analysis revealed that GLPS3 altered the composition and diversity of intestinal microbiota, especially, decreased the relative abundance of phylum Bacteroidetes and increased that of phylum Firmictutes. At the genus level, supplementation of GLPS3 increased the relative abundance of the beneficial bacteria such as Lactobacillales, Roseburia and Lachnospiraceae. These results disclosed the potential therapy mechanism of GLPS3 on chronic pancreatitis might be intestinal microbiota dependent.

KEYWORDS:

Chronic pancreatitis; Ganoderma lucidum polysaccharide; High throughput sequencing; Intestinal microbiota

PMID:
27616696
DOI:
10.1016/j.ijbiomac.2016.09.029
[Indexed for MEDLINE]

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