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Chem Asian J. 2016 Nov 7;11(21):3097-3101. doi: 10.1002/asia.201601079. Epub 2016 Oct 12.

Identification of Endocrine Disrupting Chemicals using a Virus-Based Colorimetric Sensor.

Moon JS1, Lee Y1,2, Shin DM3, Kim C1,2, Kim WG1,2, Park M4, Han J1,2, Song H5, Kim K5, Oh JW1,2,6.

Author information

1
BK21 PLUS Nano convergence Technology Division, Pusan National University, Busan, 46241, Republic of Korea.
2
Department of Nano Fusion Technology, Pusan National University, Busan, 46241, Republic of Korea.
3
Research center for Energy Convergence Technology, Pusan National University, Busan, 46241, Republic of Korea.
4
Department of Applied Nanoscience, Pusan National University, Busan, 46241, Republic of Korea.
5
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46241, Republic of Korea.
6
Department of Nanoenergy Engineering, Pusan National University, Busan, 46241, Republic of Korea.

Abstract

A simple and portable colorimetric sensor based on M13 bacteriophage (phage) was devised to identify a class of endocrine disrupting chemicals, including benzene, phthalate, and chlorobenzene derivatives. Arrays of structurally and genetically modified M13 bacteriophage were fabricated so as to produce a biomimetic colorimetric sensor, and color changes in the phage arrays in response to several benzene derivatives were characterized. The sensor was also used to classify phthalate and chlorobenzene derivatives as representatives of endocrine disrupting chemicals. The characteristic color patterns obtained on exposure to various benzene derivatives enabled similar chemical structures in the vapor phase to be classified. Our sensing approach based on the use of a genetically surface modified M13 bacteriophage offers a promising platform for portable, simple environmental monitors that could be extended for use in numerous application areas, including food monitoring, security monitoring, explosive risk assessment, and point of care testing.

KEYWORDS:

bacteriophages; endocrine disrupting chemicals; phthalates; polychlorinated biphenyls; sensors

PMID:
27616055
DOI:
10.1002/asia.201601079
[Indexed for MEDLINE]

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