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Diabetes Obes Metab. 2016 Sep;18 Suppl 1:137-43. doi: 10.1111/dom.12721.

β-Cell replacement as a treatment for type 1 diabetes: an overview of possible cell sources and current axes of research.

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Université Côte d'Azur, CNRS, Inserm, iBV, France.
Université Côte d'Azur, CNRS, Inserm, iBV, France.


To efficiently treat type 1 diabetes, exogenous insulin injections currently represent the main approach to counter chronic hyperglycaemia. Unfortunately, such a therapeutic approach does not allow for perfectly maintained glucose homeostasis and, in time, cardiovascular complications may arise. Therefore, seeking alternative/improved treatments has become a major health concern as an increasing proportion of type 2 diabetes patients also require insulin supplementation. Towards this goal, numerous laboratories have focused their research on β-cell replacement therapies. Herein, we will review the current state of this research area and describe the cell sources that could potentially be used to replenish the depleted β-cell mass in diabetic patients.


stem cells; transdifferentiation; transplantation; type 1 diabetes; β-cells

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