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Eur Arch Otorhinolaryngol. 2017 Mar;274(3):1301-1308. doi: 10.1007/s00405-016-4301-1. Epub 2016 Sep 10.

A comprehensive study of oxidative stress in sudden hearing loss.

Author information

1
Department of Otorhinolaryngology, Head and Neck Surgery, Bitlis Tatvan State Hospital, Tatvan, Bitlis, Turkey. drfatihgul@gmail.com.
2
Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk Training and Research Hospital, Ankara, Turkey.
3
Department of Otorhinolaryngology, Head and Neck Surgery, Karaman State Hospital, Karaman, Turkey.
4
Department of Otorhinolaryngology, Head and Neck Surgery, Yildirim Beyazit University School of Medicine, Ankara, Turkey.
5
Department of Clinical Biochemistry, Gaziantep 25 Aralık State Hospital, Gaziantep, Turkey.

Abstract

Little is known about the association between idiopathic sudden sensorineural hearing loss (ISSNHL) and oxidative stress. We investigated changes in a wide range of oxidants and antioxidants to create a comprehensive picture of oxidative imbalance. In the peripheral blood of 50 ISSNHL patients and 50 healthy subjects, total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), thiol/disulphide levels were measured. Moreover, a global oxidative stress index, reflecting both oxidative and antioxidant counterparts, was also calculated. One-way analysis between oxidative markers and severity of hearing loss were evaluated. The ISSNHL patients showed significantly higher TOS levels than controls (6.02 ± 3.17 vs. 4.5 ± 2.22; p = 0.018). The oxidative index was also significantly higher in patients than controls (0.39 ± 0.19 vs. 0.3 ± 0.14; p = 0.035). TAS, PON, native thiol, and total thiol were not altered. There was no statistical significance between oxidative markers and severity of hearing loss. The binary logistic regression model revealed that disulphide and TOS were associated with ISSNHL. There are alterations in a wide array of oxidants and antioxidants, with balance shifting toward increased oxidative stress in ISSNHL. Our findings may suggest endothelial dysfunction in ISSNHL etiopathogenesis.

KEYWORDS:

Oxidative stress; Paraoxonase; Sudden sensorineural hearing loss; Thiol/disulphide homeostasis; Total antioxidant status; Total oxidant status

PMID:
27614879
DOI:
10.1007/s00405-016-4301-1
[Indexed for MEDLINE]

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