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Trends Immunol. 2016 Nov;37(11):724-737. doi: 10.1016/j.it.2016.08.010. Epub 2016 Sep 7.

Present Yourself! By MHC Class I and MHC Class II Molecules.

Author information

1
Department of Pathology, UMass Medical School, Worcester, MA, USA.
2
Department of Cell Biology and Histology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
3
Department of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Chemical Immunology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: J.J.C.Neefjes@lumc.nl.

Abstract

Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell response, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review of the ins and outs of MHC class I and MHC class II antigen presentation.

KEYWORDS:

MHC class I; MHC class II; antigen presentation; autoimmune diseases; transplantation; tumor immunology

PMID:
27614798
PMCID:
PMC5159193
DOI:
10.1016/j.it.2016.08.010
[Indexed for MEDLINE]
Free PMC Article

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