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Am J Clin Pathol. 2016 Dec;146(6):741-746. doi: 10.1093/ajcp/aqw128. Epub 2016 Sep 10.

Fine-Needle Aspiration of Epithelial-Myoepithelial Carcinoma of the Parotid Gland With Prominent Adenoid Cystic Carcinoma-Like Cribriform Features: Avoiding a Diagnostic Pitfall.

Author information

1
From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston oaisagbonhi@partners.org.
2
Department of Pathology, North Shore Medical Center, Salem, MA.
3
From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.
4
Department of Pathology, Lahey Hospital and Medical Center, Burlington, MA.

Abstract

OBJECTIVES:

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland malignancy associated with an overall good prognosis. Fine-needle aspiration (FNA) typically shows a dual population of myoepithelial and ductal cells. Rarely, acellular matrix globules are present, raising a differential diagnosis of adenoid cystic carcinoma (AdCC), a more aggressive salivary gland malignancy associated with a poor long-term prognosis. We report an FNA case of EMC containing a predominant pattern of AdCC-like spherical globules.

METHODS:

We compare features of an unusual case of EMC with those of cribriform AdCC to arrive at morphologic clues to the correct diagnosis.

RESULTS:

Distinguishing features of EMC on FNA include (1) a prominent population of myoepithelial cells vs the predominance of basaloid cells in AdCC and (2) cohesive matrix globules with a peripheral rim of pale-staining basement membrane material compared with the dyscohesive matrix globules of AdCC. Immunochemical markers (S100, CD117, and MyB) are also useful.

CONCLUSIONS:

Although EMC and AdCC can both contain spherical matrix globules, close evaluation of the cytomorphology of the globules and their relationship to surrounding cells provides a clue to distinguish the two neoplasms.

KEYWORDS:

Adenoid cystic carcinoma; Epithelial-myoepithelial carcinoma; Fine-needle aspiration; Salivary gland

PMID:
27614667
DOI:
10.1093/ajcp/aqw128
[Indexed for MEDLINE]

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