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Cancer Radiother. 2016 Oct;20(6-7):622-8. doi: 10.1016/j.canrad.2016.07.088. Epub 2016 Sep 7.

CTV to PTV in cervical cancer: From static margins to adaptive radiotherapy.

Author information

1
Radiation Oncology Department, Gustave-Roussy Cancer Campus, Paris-Sud University, 94805 Villejuif cedex, France. Electronic address: roger.sun@gustaveroussy.fr.
2
Radiation Oncology Department, Gustave-Roussy Cancer Campus, Paris-Sud University, 94805 Villejuif cedex, France.
3
Radiation Oncology Department, Bretonneau University Hospital, 37000 Tours, France; François-Rabelais University, 37000 Tours, France.

Abstract

Intensity-modulated radiotherapy (IMRT) is increasingly used in order to minimize the gastrointestinal, genitourinary, and hematological toxicity in cervical and uterine cancers. However, the benefit of this high-precision approach is detracted by the margins applied to the clinical target volume (CTV) to generate the planning tumor volume (PTV), taking into account tumor and surrounding organs movements, deformations, and volume changes. Adequate PTV margins should be large enough to prevent geographical misses, but not excessive, which might end the benefit from IMRT. The objectives of this review were: (a) to present the evidence available for the determination of CTV-PTV margin for uterine cancers; (b) to highlight the impact of these margins in the context of adaptive radiotherapy; and

KEYWORDS:

Brachytherapy; Cancer du col; Curiethérapie; IMRT; PTV; Radiotherapy; Radiothérapie; Radiothérapie conformationnelle avec modulation d’intensité; Uterine cervical neoplasms; Volume cible prévisionnel

PMID:
27614513
DOI:
10.1016/j.canrad.2016.07.088
[Indexed for MEDLINE]

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