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Braz J Infect Dis. 2016 Nov - Dec;20(6):534-538. doi: 10.1016/j.bjid.2016.07.015. Epub 2016 Sep 8.

To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori.

Author information

1
Qazvin University of Medical Sciences, Velayat Clinical Research Development Unit, Department of Internal Medicine, Qazvin, Iran.
2
Qazvin University of Medical Sciences, Metabolic Diseases Research Center, Qazvin, Iran.
3
Qazvin University of Medical Sciences, Velayat Clinical Research Development Unit, Department of Internal Medicine, Qazvin, Iran. Electronic address: SRMDFM@gmail.com.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen.

METHODS:

In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software.

RESULTS:

Mean ages and SD were 38.8±10.9 and 40.1±10.4 for the study and control groups, respectively, statistically similar. Peptic ulcer was found in 30% of both groups. Response to treatment was 83.3% and 62.5% in the study and control groups, respectively. This difference was statistically significant.

CONCLUSION:

Addition of licorice to the triple clarithromycin-based regimen increases H. pylori eradication, especially in the presence of peptic ulcer disease.

KEYWORDS:

Dyspepsia; Helicobacter pylori; Licorice; Peptic ulcer

PMID:
27614124
DOI:
10.1016/j.bjid.2016.07.015
[Indexed for MEDLINE]
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