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Braz J Infect Dis. 2016 Nov - Dec;20(6):564-568. doi: 10.1016/j.bjid.2016.08.003. Epub 2016 Sep 6.

Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population.

Author information

1
Shaanxi Provincial People's Hospital, Clinical Laboratory, Xi'an, China. Electronic address: yjun512@126.com.
2
Shaanxi Provincial People's Hospital, Department of CT, Xi'an, China.
3
Shaanxi Provincial People's Hospital, Clinical Laboratory, Xi'an, China.

Abstract

OBJECTIVE:

Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1 in the immune-response to HBV, we conducted this case-control study.

METHODS:

We recruited 276 patients (145 men and 131 women; average age, 51.6 years) with chronic HBV infection (CHB) and 303 healthy controls (166 men and 137 women; average age, 54.2 years). All the subjects were unrelated individuals of Chinese Han Population. Three SNPs of PRKAA1gene were tested.

RESULTS:

Rs1002424 polymorphism showed significant difference in the allele frequencies, but no difference in the genotype frequencies (allele: p=0.039411, OR95%CI=0.783479 [0.621067-0.988362]; genotype: p=0.104758); rs13361707 polymorphism showed significance in allele analysis, but not in genotype analysis (allele: p=0.034749, OR95%CI=1.284303 [1.017958-1.620335]; genotype: p=0.098027); rs3792822 polymorphism was demonstrated to have significant differences in both genotype and allele frequencies between cases and controls (allele: p=0.029286, OR95%CI= 0.741519 [0.566439-0.970716]; genotype: p=0.034560). The haplotype results showed that CTG and TCA in the rs13361707-rs1002424-rs3792822 block were significantly associated with the happening of HBV (CTG: p=0.036854, OR95%CI=1.281 [1.015-1.617]; p=0.030841, OR95%CI=0.743 [0.568-0.973]).

CONCLUSION:

These findings suggest that PRKAA1 polymorphisms may contribute to the susceptibility of chronic HBV infection in Chinese Han origin.

KEYWORDS:

Association study; HBV; PRKAA1 gene; SNP

PMID:
27612659
DOI:
10.1016/j.bjid.2016.08.003
[Indexed for MEDLINE]
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