Optical sensors to gain mechanistic insights into signaling assemblies

Brian Tenner; Sohum Mehta; Jin Zhang

doi:10.1016/j.sbi.2016.07.021

Optical sensors to gain mechanistic insights into signaling assemblies

Curr Opin Struct Biol. 2016 Dec:41:203-210. doi: 10.1016/j.sbi.2016.07.021. Epub 2016 Sep 6.

Authors

Brian Tenner¹, Sohum Mehta², Jin Zhang³

Affiliations

¹ Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, United States.
² Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
³ Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address: jzhang32@ucsd.edu.

Abstract

Protein complexes play a major role in transducing information from outside the cell into instructions for growth and survival, and understanding how these complexes relay and shape intracellular signals has been a central question in signaling biology. Fluorescent proteins have proven paramount in opening windows for researchers to peer into the architecture and inner workings of signaling assemblies within the living cell and in real-time. In this review, we will provide readers with a current perspective on the development and use of genetically encoded optical probes to dissect the function of signaling complexes.

Optical sensors to gain mechanistic insights into signaling assemblies

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Abstract

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