Send to

Choose Destination
ACS Appl Mater Interfaces. 2016 Oct 5;8(39):25770-25776. Epub 2016 Sep 22.

Gd@C82-(ethylenediamine)8 Nanoparticle: A New High-Efficiency Water-Soluble ROS Scavenger.

Li J1,2, Guan M1,2, Wang T1, Zhen M1,2, Zhao F1,2, Shu C1, Wang C1,2.

Author information

Beijing National Laboratory for Molecular Sciences, Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.


It is important to maintain a reactive oxygen species (ROS) balance in organisms; thus, a valid ROS scavenger with good biocompatibility is urgently required. To prepare a high-efficiency ROS scavenger, multiple ethylenediamine (EDA) groups are bonded for the first time to a metallofullerene Gd@C82 to obtain water-soluble Gd@C82-(EDA)8 nanoparticles (NPs) through a facile solid-liquid reaction. Gd@C82-(EDA)8 NPs with a relatively better conjugation possess an excellent capability to scavenge hydroxyl radicals. Moreover, Gd@C82-(EDA)8 NPs exhibited a remarkable cytoprotective effect against H2O2-induced injuries to human epidermal keratinocytes-adult (HEK-a) cells at a low concentration of 2.5 μM. In contrast, Gd@C82-(OH)26 NPs that modified with hydroxyls show an apparent protective effect at a much higher concentration of 40 μM. This outstanding cytoprotective performance of Gd@C82-(EDA)8 NPs is mainly attributed to their extremely high cellular uptake and comparably strong conjugation. Gd@C82-(EDA)8 NPs with good biocompatibility exhibit excellent ROS scavenging capability even at a significantly low concentration, which promotes its versatile applications in cosmetics and biomedicine.


Gd@C82-(EDA)8 nanoparticles; ROS scavenger; cellular uptake; conjugation; cytoprotective effect

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center