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ACS Appl Mater Interfaces. 2016 Oct 5;8(39):25770-25776. Epub 2016 Sep 22.

Gd@C82-(ethylenediamine)8 Nanoparticle: A New High-Efficiency Water-Soluble ROS Scavenger.

Li J1,2, Guan M1,2, Wang T1, Zhen M1,2, Zhao F1,2, Shu C1, Wang C1,2.

Author information

1
Beijing National Laboratory for Molecular Sciences, Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
2
University of Chinese Academy of Sciences, Beijing 100049, China.

Abstract

It is important to maintain a reactive oxygen species (ROS) balance in organisms; thus, a valid ROS scavenger with good biocompatibility is urgently required. To prepare a high-efficiency ROS scavenger, multiple ethylenediamine (EDA) groups are bonded for the first time to a metallofullerene Gd@C82 to obtain water-soluble Gd@C82-(EDA)8 nanoparticles (NPs) through a facile solid-liquid reaction. Gd@C82-(EDA)8 NPs with a relatively better conjugation possess an excellent capability to scavenge hydroxyl radicals. Moreover, Gd@C82-(EDA)8 NPs exhibited a remarkable cytoprotective effect against H2O2-induced injuries to human epidermal keratinocytes-adult (HEK-a) cells at a low concentration of 2.5 μM. In contrast, Gd@C82-(OH)26 NPs that modified with hydroxyls show an apparent protective effect at a much higher concentration of 40 μM. This outstanding cytoprotective performance of Gd@C82-(EDA)8 NPs is mainly attributed to their extremely high cellular uptake and comparably strong conjugation. Gd@C82-(EDA)8 NPs with good biocompatibility exhibit excellent ROS scavenging capability even at a significantly low concentration, which promotes its versatile applications in cosmetics and biomedicine.

KEYWORDS:

Gd@C82-(EDA)8 nanoparticles; ROS scavenger; cellular uptake; conjugation; cytoprotective effect

PMID:
27610478
DOI:
10.1021/acsami.6b08659
[Indexed for MEDLINE]

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