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Open J Clin Med Case Rep. 2016;2(11). pii: 1121.

Low-Resolution Electromagnetic Tomography (LORETA) of changed Brain Function Provoked by Pro-Dopamine Regulator (KB220z) in one Adult ADHD case.

Author information

1
Department of Psychology, Curry College, Milton, MA, USA.
2
Department of Psychiatry & McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL., USA; Department of Psychiatry and Behavioral Sciences, Keck Medicine University of Southern California, Los Angeles, CA, USA; Division of Applied Clinical Research & Education, Dominion Diagnostics, LLC, North Kingstown, RI, USA; Department of Neurogenomics, Igene, LLC, Austin, Tx, USA; Division of Neuroscience- Based Therapy, Summit Estate Recovery Center, Las Gatos, CA, USA; Department of Addiction Research & Therapy, LaVita RDS, Salt Lake City, UT, USA; Department of Clinical Neurology, Path Foundation NY, NewYork, NY, USA.
3
Center for Psychiatric Medicine North Andover, MA, USA.
4
Department of Psychology, University of Tennessee and Southeastern Neurofeedback Institute, Knoxville, TN, USA.
5
Department of Psychiatry & McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL., USA.
6
Department of Clinical Neurology, Path Foundation NY, NewYork, NY, USA.
7
Department of Psychiatry, Laboratory of Molecular and Functional Imaging, University of Minnesota, Minneapolis, MN., USA.

Abstract

Attention Deficit-Hyperactivity Disorder (ADHD) often continues into adulthood. Recent neuroimaging studies found lowered baseline dopamine tone in the brains of affected individuals that may place them at risk for Substance Use Disorder (SUD). This is an observational case study of the potential for novel management of Adult ADHD with a non-addictive glutaminergic-dopaminergic optimization complex KB200z. Low-resolution electromagnetic tomography (LORETA) was used to evaluate the effects of KB220z on a 72-year-old male with ADHD, at baseline and one hour following administration. The resultant z-scores, averaged across Eyes Closed, Eyes Open and Working Memory conditions, increased for each frequency band, in the anterior, dorsal and posterior cingulate regions, as well as the right dorsolateral prefrontal cortex during Working Memory, with KB220z. These scores are consistent with other human and animal neuroimaging studies that demonstrated increased connectivity volumes in reward circuitry and may offer a new approach to ADHD treatment. However, larger randomized trials to confirm these results are required.

KEYWORDS:

Attention Deficit-Hyperactivity Disorder (ADHD); Cingulate Gyrus; Dopamine; Kb220z; Low-resolution electromagnetic tomography (LORETA); Prefrontal Cortices

PMID:
27610420
PMCID:
PMC5012539

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