Genome Sequence of a Clinical Strain of Acinetobacter baumannii Belonging to the ST79/PFGE-HUI-1 Clone Lacking the AdeABC (Resistance-Nodulation-Cell Division-Type) Efflux Pump

M López; L Álvarez-Fraga; E Gato; L Blasco; M Poza; L Fernández-García; G Bou; M Tomás

doi:10.1128/genomeA.00962-16

Genome Sequence of a Clinical Strain of Acinetobacter baumannii Belonging to the ST79/PFGE-HUI-1 Clone Lacking the AdeABC (Resistance-Nodulation-Cell Division-Type) Efflux Pump

Genome Announc. 2016 Sep 8;4(5):e00962-16. doi: 10.1128/genomeA.00962-16.

Authors

M López¹, L Álvarez-Fraga¹, E Gato¹, L Blasco², M Poza¹, L Fernández-García, G Bou¹, M Tomás³

Affiliations

¹ Department of Microbiology, Complejo Hospitalario Universitario A Coruña-INIBIC, La Coruña, Spain Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Hospital Universitario Virgen Macarena, Sevilla, Spain.
² Department of Microbiology, Complejo Hospitalario Universitario A Coruña-INIBIC, La Coruña, Spain.
³ Department of Microbiology, Complejo Hospitalario Universitario A Coruña-INIBIC, La Coruña, Spain Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), Hospital Universitario Virgen Macarena, Sevilla, Spain MA.del.Mar.Tomas.Carmona@sergas.es.

Abstract

Increased expression of chromosomal genes for resistance-nodulation-cell division-type efflux systems plays a major role in the multidrug resistance of Acinetobacter baumannii Little is known about the genetic characteristics of clinical strains of Acinetobacter baumannii lacking the AdeABC pump. In this study, we sequenced the genome of clinical strain Ab421 GEIH-2010 (belonging to clone ST79/PFGE-HUI-1 from the GEIH-REIPI Ab. 2010 project) which lacks this efflux pump.

Grants and funding

This study was funded by grants PI10/00056 and PI13/02390 awarded to M.T., grant PI12/00552 awarded to G.B., and grant PI11/01034 awarded to M.P. within the State Plan for R + D + I 2013-2016 (National Plan for Scientific Research, Technological Development and Innovation, 2008-2011). It was cofinanced by the ISCIII-Deputy General Directorate of Evaluation and Promotion of Research-European Regional Development Fund “A Way of Making Europe” and the Instituto de Salud Carlos III FEDER, Spanish Network for Research in Infectious Diseases (REIPI RD12/0015). M.T. was financially supported by the Miguel Servet Research Programme (C.H.U.A Coruña and ISCIII).