Format

Send to

Choose Destination
Rev Port Cardiol. 2016 Oct;35(10):525-30. doi: 10.1016/j.repc.2016.04.010. Epub 2016 Sep 5.

Epicardial fat tissue thickness is increased in patients with lichen planus and is linked to inflammation and dyslipidemia.

[Article in English, Portuguese]

Author information

1
Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey. Electronic address: agertem@hotmail.com.
2
Department of Cardiology, Yildirim Beyazit University, Ankara, Turkey.
3
Department of Cardiology, Tokat State Hospital, Tokat, Turkey.
4
Department of Dermatology, Yildirim Beyazit University, Ankara, Turkey.
5
Department of Dermatology, Tokat State Hospital, Tokat, Turkey.

Abstract

BACKGROUND AND OBJECTIVES:

Lichen planus (LP) is a mucocutaneous inflammatory disease. Inflammation plays a major role in the progression of atherosclerosis. Epicardial fat tissue (EFT) has been shown to produce and secrete various proatherogenic and proinflammatory hormones and cytokines. The aim of this study was to assess EFT in patients with lichen planus.

METHODS:

Fifty-four patients with LP and 50 controls were enrolled in the study. LP was diagnosed according to the World Health Organization criteria. EFT was measured on the free wall of the right ventricle in parasternal long-axis view, as previously described and validated.

RESULTS:

There were positive correlations between EFT thickness and platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, duration of LP, and high-sensitivity C-reactive protein (hsCRP) (p<0.001, p<0.001, p=0.002 and p<0.001, respectively). In multivariate analysis, after adjustments for relevant confounders, LDL cholesterol, hsCRP, platelet/lymphocyte ratio and duration of LP were independent predictors of EFT thickness in patients with LP (β=0.231, p=0.014; β=0.205, p=0.037; β=0.361, p=0.001 and β=0.133, p=0.047, respectively).

CONCLUSION:

EFT is increased in patients with LP compared to control subjects. Duration of LP is correlated with EFT, and duration of LP is also an independent predictor of increased EFT, which is a predictor of subclinical atherosclerosis.

KEYWORDS:

Echocardiography; Ecocardiograma; Epicardial fat tissue; Lichen planus; Líquen plano; Tecido adiposo epicárdico

PMID:
27609552
DOI:
10.1016/j.repc.2016.04.010
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center