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Sci Rep. 2016 Sep 9;6:33073. doi: 10.1038/srep33073.

Higher Levels of Lipoprotein Associated Phospholipase A2 is associated with Increased Prevalence of Cognitive Impairment: the APAC Study.

Jiang R1,2,3,4, Chen S1,2,3,4, Shen Y1,2,3,4, Wu J1,2,3,4, Chen S5, Wang A1,2,3,4,6, Wu S5, Zhao X1,2,3,4.

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Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100050, China.
China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100050, China.
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, 100050, China.
Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, 063000, China.
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, 100050, China.


Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a unique circulating phospholipase with inflammatory and oxidative activities and the limited data regarding the relationship between Lp-PLA2 and cognitive impairment are conflicted. We conducted a cross-sectional study including 1,374 Chinese adults recruited from 2010 to 2011, aiming to evaluate the relationship between Lp-PLA2 levels and the prevalence of cognitive impairment in a Chinese community-based population. Participants underwent standardized evaluation. Serum Lp-PLA2 mass was measured by ELISA. Cognition status was evaluated via the Mini-Mental Status Exam (MMSE) and cognitive impairment was identified as MMSE <24. Multivariable logistic regression models were used to assess the associations of Lp-PLA2 mass with cognitive impairment. Lp-PLA2 mass was significantly associated with the prevalence of cognitive impairment after adjusting for other potential confounding factors (compared with the first quartile, adjusted ORs of the second, third, and fourth quartile were 2.058 (95% CI, 0.876-4.835), 2.834 (95% CI, 1.255-6.398), and 4.882 (95% CI, 2.212-10.777), p < 0.0001). In conclusion, elevated level of Lp-PLA2 mass was independently associated with the prevalence of cognitive impairment in Chinese adults.

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