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IUBMB Life. 2016 Oct;68(10):783-91. doi: 10.1002/iub.1556. Epub 2016 Sep 7.

Molecular basis of antibody-mediated neutralization and protection against flavivirus.

Dai L1, Wang Q2,3, Qi J4, Shi Y5,3,4,6,7, Yan J2,3,4,7, Gao GF8,9,10,11,12,13.

Author information

1
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China. dailp@biols.ac.cn.
2
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
3
Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China.
4
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
5
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
6
Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, China.
7
Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
8
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China. gaof@im.ac.cn.
9
Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China. gaof@im.ac.cn.
10
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. gaof@im.ac.cn.
11
Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, China. gaof@im.ac.cn.
12
Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. gaof@im.ac.cn.
13
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China. gaof@im.ac.cn.

Abstract

Antibody-mediated humoral immunity plays a pivotal role in flavivirus control. Neutralizing antibodies targeting viral envelope (E) protein, provide protection against flaviviruses in vivo but can also promote virus infection by antibody-dependent enhancement when antibodies are weakly neutralizing or in subneutralizing concentrations. The molecular basis for antibody-mediated virus neutralization can be revealed by structural studies of monoclonal antibodies complexed with the E protein or virion. In addition, the flavivirus non-structural protein NS1 can also induce host antibody production, and some of these antibodies can provide protection against virus challenge. In this review, we summarize the known structures of flavivirus neutralizing or protective antibodies bound to their epitopes and describe the underlying molecular mechanisms.

KEYWORDS:

antibodies; flavivirus; neutralization; protection; structural basis

PMID:
27604155
DOI:
10.1002/iub.1556
[Indexed for MEDLINE]
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