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Cell Commun Adhes. 2015 Apr - Dec;22(2-6):67-78. Epub 2016 Sep 7.

Glycolaldehyde-derived advanced glycation end products (glycol-AGEs)-induced vascular smooth muscle cell dysfunction is regulated by the AGES-receptor (RAGE) axis in endothelium.

Author information

1
a Department of Biotechnology , College of Life Science and Biotechnology, Korea University , Seoul , South Korea.
2
b Division of Biotechnology , College of Life Sciences and Biotechnology, Korea University , Seoul , South Korea.

Abstract

Advanced glycation end-products (AGEs) are involved in the development of vascular smooth muscle cell (VSMC) dysfunction and the progression of atherosclerosis. However, AGEs may indirectly affect VSMCs via AGEs-induced signal transduction between monocytes and human umbilical endothelial cells (HUVECs), rather than having a direct influence. This study was designed to elucidate the signaling pathway underlying AGEs-RAGE axis influence on VSMC dysfunction using a co-culture system with monocytes, HUVECs and VSMCs. AGEs stimulated production of reactive oxygen species and pro-inflammatory mediators such as tumor necrosis factor-α and interleukin-1β via extracellular-signal-regulated kinases phosphorylation and nuclear factor-κB activation in HUVECs. It was observed that AGEs-induced pro-inflammatory cytokines increase VSMC proliferation, inflammation and vascular remodeling in the co-culture system. This result implies that RAGE plays a role in AGEs-induced VSMC dysfunction. We suggest that the regulation of signal transduction via the AGEs-RAGE axis in the endothelium can be a therapeutic target for preventing atherosclerosis.

KEYWORDS:

Advanced glycation end-products; inflammatory cytokines; reactive oxygen species; vascular dysfunction

PMID:
27602595
DOI:
10.1080/15419061.2016.1225196
[Indexed for MEDLINE]

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