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J Org Chem. 2016 Oct 7;81(19):9389-9395. Epub 2016 Sep 15.

Iron-Mediated Annulation between Methylene Ketones and Diethanolamines: A Sustainable and Scalable Procedure toward N-(2-Hydroxyethyl) Pyrroles.

Author information

1
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University , Changzhou 213164, PR China.

Abstract

An iron-mediated direct annulation between methylene ketones and diethanolamines was developed for the efficient synthesis of N-(2-hydroxyethyl) pyrroles. This protocol shows high efficiency, operational simplicity, good functional group compatibility as well as broad substrates scope.

PMID:
27602510
DOI:
10.1021/acs.joc.6b01195

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