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Biomed Rep. 2016 Sep;5(3):283-288. Epub 2016 Jul 18.

Potential role of bromelain in clinical and therapeutic applications.

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Department of Oral Pathology and Microbiology, Faculty of Dental Science, Sri Ramachandra University, Chennai, Tamilnadu 600116, India.
Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Department of Physics, K. S. Rangasamy College of Technology, Tiruchengode, Tamilnadu 637215, India.
Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, University Putra Malaysia, Serdang, Selangor 43400, Malaysia.
Department of Physics, Periyar University, Salem, Tamilnadu 636011, India.


Pineapple has been used as part of traditional folk medicine since ancient times and it continues to be present in various herbal preparations. Bromelain is a complex mixture of protease extracted from the fruit or stem of the pineapple plant. Although the complete molecular mechanism of action of bromelain has not been completely identified, bromelain gained universal acceptability as a phytotherapeutic agent due to its history of safe use and lack of side effects. Bromelain is widely administered for its well-recognized properties, such as its anti-inflammatory, antithrombotic and fibrinolytic affects, anticancer activity and immunomodulatory effects, in addition to being a wound healing and circulatory improvement agent. The current review describes the promising clinical applications and therapeutic properties of bromelain.


anti-microbial; anticancer; bromelain; inflammation; pineapple; therapeutics

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