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Diabetes Metab Syndr Obes. 2016 Aug 25;9:281-310. doi: 10.2147/DMSO.S95120. eCollection 2016.

Role of sleep quality in the metabolic syndrome.

Author information

1
Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine; Section of Pediatric Sleep Medicine.
2
Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine.
3
Section of Pediatric Sleep Medicine; Section of Pulmonology, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA.

Abstract

Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.

KEYWORDS:

cardiovascular risk; circadian clock; insulin resistance; obesity; sleep apnea

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