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J Muscle Res Cell Motil. 1989 Apr;10(2):101-12.

Caldesmon and the structure of smooth muscle thin filaments: immunolocalization of caldesmon on thin filaments.

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  • 1Department of Physiology, Boston University School of Medicine, Massachusetts 02118.


Antibodies reacting with chicken gizzard caldesmon were used to determine the distribution of caldesmon on smooth muscle thin filaments. Antibodies developed against both the intact caldesmon molecule and a 40 kilodalton proteolytic fragment cause thin filaments to aggregate laterally. Aggregates produced with the latter antibody display regular periodic labelling with a repeat of approximately 38 nm, a distribution characteristic of proteins associated with tropomyosin on thin filaments. The stoichiometry of caldesmon on thin filaments has been critically reevaluated and alternative models of caldesmon distribution on thin filaments are proposed.

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