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Arch Clin Neuropsychol. 2016 Dec 1;31(8):868-876. doi: 10.1093/arclin/acw072.

Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study.

Author information

1
eCampus University, Novedrate, Como, Italy.
2
Department of Mental Health , Azienda Sanitaria Locale Torino 3, Collegno, Torino, Italy.
3
Assisted Health Residence "Ville Roddolo" , Moncalieri, Torino, Italy.
4
Canterbury Christ Church University, Department of Psychology, Politics and Sociology , Tunbridge Wells, England (UK).
5
Leiden University, Department of Psychology, Section Health, Medical and Neuropsychology , Leiden, The Netherlands.

Abstract

INTRODUCTION:

Alzheimer's disease (AD) presents with significant neuropsychological deficits. Cognitive training in AD has recently started to demonstrate its efficacy. In this study, we implemented computerized cognitive training of a large group of early-stage AD patients, to identify its effects at a neuropsychological level and to investigate whether they were stable after 6 months.

METHOD:

Overall, 80 AD patients were randomized in two groups. Patients in the experimental group used a structured rehabilitative software three times a week for 12 consecutive weeks aimed at training memory, attention, executive function and language skills, whereas patients in the control group underwent a control intervention.

RESULTS:

A Repeated Measures General Linear Model considering groups' performance at the three assessment points (before training, after training and at the 6-month follow-up) showed a significant interaction effect for: digit span forward (F(2,74) = 2.785, p = 0.03) and backward (F(2,74) = 3.183, p = 0.02), two-syllable words test (F(2,74) = 3.491, p = 0.004), Rivermead Behavioural Memory Test immediate (F(2,74) = 2.877, p = 0.03) and delayed (F(2,74) = 3.783, p = 0.003), Token test (F(2,74) = 4.783, p = 0.001), and Brixton test (F(2,74) = 8.783, p < 0.001). For all of them, experimental group performed better than controls.

CONCLUSIONS:

Patients in the experimental group showed a significant improvement in various neuropsychological domains, and their achievements were stable after 6 months. This study suggests an useful computerized training in AD, and should prompt further investigations about the generalizability of patients' acquired skills to more ecologically oriented tasks.

KEYWORDS:

Alzheimer's disease; Cognitive training; Memory; Neuropsychology; Rehabilitation

PMID:
27600448
DOI:
10.1093/arclin/acw072

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