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Skeletal Radiol. 2016 Nov;45(11):1565-9. doi: 10.1007/s00256-016-2460-1. Epub 2016 Sep 6.

Intraosseous hibernoma: a rare adipocytic bone tumour.

Author information

1
Department of Radiology, Nuffield Orthopaedic Centre, Oxford, UK.
2
Orthopaedic Surgery, Nuffield Orthopaedic Centre, Oxford, UK.
3
Department of Pathology, Nuffield Orthopaedic Centre, Oxford, UK. nick.athanasou@ndorms.ox.ac.uk.
4
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE, UK. nick.athanasou@ndorms.ox.ac.uk.

Abstract

Hibernoma is a benign adipose tumour that contains foetal brown fat cells. We report a case of hibernoma arising in the left ischium of a 65-year-old female with a past history of ovarian carcinoma. The patient presented with a relatively short history of left sacral/hip pain. Radiologically, the lesion, which was large (5 cm) and sclerotic, had been stable for a number of years. Histologically, it was composed mainly of plump cells with foamy, multivacuolated cytoplasm. These cells showed no reaction for epithelial, melanoma or leucocyte markers but expressed FABP4/aP2 and S100, indicating that they were brown fat cells. There was no mitotic activity or nuclear pleomorphism and the lesion was diagnosed as a benign intraosseous hibernoma (IOH). IOH is a recently identified benign adipocytic lesion that presents typically as a sclerotic bone lesion. It has characteristic morphological and immunophenotypic features and should be regarded as a discrete primary bone tumour that needs to be distinguished from metastatic carcinoma/melanoma, chondrosarcoma and metabolic storage diseases containing numerous foamy macrophages.

KEYWORDS:

Adipose tissue; Bone tumour; Hibernoma; Pelvis

PMID:
27600140
DOI:
10.1007/s00256-016-2460-1
[Indexed for MEDLINE]

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