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Dokl Biochem Biophys. 2016 Jul;469(1):239-43. doi: 10.1134/S1607672916040025. Epub 2016 Sep 7.

Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide.

Author information

1
Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.
2
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
3
Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia. mg-vinokurov@mail.ru.

Abstract

The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1β mRNA in SK-N-SH cells induced by LPS.

PMID:
27599502
DOI:
10.1134/S1607672916040025
[Indexed for MEDLINE]

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