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Int J Mol Sci. 2016 Sep 1;17(9). pii: E1448. doi: 10.3390/ijms17091448.

Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster.

Author information

1
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. medsnutk@gmail.com.
2
Department of Dermatology, College of medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, Korea. victoryby777@gmail.com.
3
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. u2u2star@gmail.com.
4
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. algp_@naver.com.
5
MJ All Skin Clinic, Seoul 04537, Korea. mjallskin@gmail.com.
6
YeMiWon Clinic, Seoul 06280, Korea. dermacsyoun@hanmail.net.
7
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. miumiu@amc.seoul.kr.
8
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea. csesnumd@gmail.com.

Abstract

Polydeoxyribonucleotide (PDRN), a deoxyribonucleotide polymer, is popularly used for faster healing of cutaneous wounds and boosting of neocollagenesis of photoaged skin among current dermatologic practitioners. Some patients receiving PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP). To investigate the effect of PDRN on cutaneous melanogenesis, we examined the effect of PDRN and an available product (Placentex(®)) containing PDRN on melanogenesis using human melanocytes-keratinocytes cocultures and mouse melanocytes. Melanin content, tyrosinase activity, and levels of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein (TRP-1) were determined. Intracellular signaling pathways were assessed by Western blotting. PDRN and Placentex(®) led to decreases in melanin content, tyrosinase activity, and MITF and TRP-1 expression with concomitant increases in phosphorylated forms of extracellular signal-regulated protein kinase (ERK) and AKT in mouse melanocytes. More importantly, both PDRN and Placentex(®) significantly suppressed the melanin content in human melanocyte-keratinocyte cocultures. Clinical evaluation of six female patients with facial hyperpigmentation after three sessions of intradermal PDRN injections using a 5-point scale revealed that PDRN led to more than noticeable improvements in hyperpigmented lesions. This is the first study to demonstrate that PDRN, which is known for its wound-healing properties, may have novel anti-melanogenesis and potential skin whitening properties.

KEYWORDS:

coculture; hyperpigmentation; melanogenesis; polydeoxyribonucleotide

PMID:
27598132
PMCID:
PMC5037727
DOI:
10.3390/ijms17091448
[Indexed for MEDLINE]
Free PMC Article

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