Format

Send to

Choose Destination
J Immunol Res. 2016;2016:5457010. doi: 10.1155/2016/5457010. Epub 2016 Aug 15.

In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity.

Author information

1
Division of Research and Development, SANYpet SpA, 35023 Bagnoli di Sopra, Italy.
2
School of Specialization in Clinical Biochemistry, "G. d'Annunzio" University, 66100 Chieti, Italy.
3
Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.
4
Ph.D. School of Science, University of Basilicata, 85100 Potenza, Italy.
5
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80100 Naples, Italy.
6
Department of Science, University of Basilicata, 85100 Potenza, Italy.
7
Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy; Department of Science, University of Basilicata, 85100 Potenza, Italy.

Abstract

Several extrinsic factors, like drugs and chemicals, can foster autoimmunity. Tetracyclines, in particular oxytetracycline (OTC), appear to correlate with the emergence of immune-mediated diseases. Accumulation of OTC, the elective drug for gastrointestinal and respiratory infectious disease treatment in broiler chickens, was reported in chicken edible tissues and could represent a potential risk for pets and humans that could assume this antibiotic as residue in meat or in meat-derived byproducts. We investigated the in vitro anti-inflammatory properties of a pool of thirteen botanicals as a part of a nutraceutical diet, with proven immunomodulatory activity. In addition, we evaluated the effect of such botanicals in contrasting the in vitro proinflammatory toxicity of OTC. Our results showed a significant reduction in interferon- (INF-) γ production by human and canine lymphocytes in presence of botanicals ((⁎) p < 0.05). Increased INF-γ production, dependent on 24-hour OTC-incubation of T lymphocytes, was significantly reduced by the coincubation with Haematococcus pluvialis, with Glycine max, and with the mix of all botanicals ((⁎) p < 0.05). In conclusion, the use of these botanicals was shown to be able to contrast OTC-toxicity and could represent a new approach for the development of functional foods useful to enhance the standard pharmacological treatment in infections as well as in preventing or reducing the emergence of inflammatory diseases.

PMID:
27597982
PMCID:
PMC5002466
DOI:
10.1155/2016/5457010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center