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Neurol Res. 2016 Oct;38(10):888-92. doi: 10.1080/01616412.2016.1227913. Epub 2016 Sep 6.

High dose Vitamin D intake and quality of life in relapsing-remitting multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial.

Author information

1
a Department of Neurology , Isfahan University of Medical sciences , Isfahan , Iran.
2
b Isfahan Neuroscience Research Center , Isfahan University of Medical Sciences , Isfahan , Iran.
3
c Department of Biology , University Of Isfahan , Isfahan , Iran.
4
d Department of Biostatistics and Epidemiology, Health School , Isfahan University of Medical Sciences , Isfahan , Iran.

Abstract

BACKGROUND:

Low level of vitamin D is associated with a more severe course and low quality of life in relapsing-remitting multiple sclerosis (RRMS). Low dose vitamin D intake has improved quality of life in RRMS patients.

OBJECTIVE:

This study explored the effect of high dose vitamin D intake on quality of life in RRMS patients in a double blind randomized clinical trial.

METHODS:

94 RRMS patients were randomized to two groups. One group received 50,000 IU vitamin D3 every five days for 3 months. The other group received placebo. Interferon-β (IFN-β) continued as the main treatment in both groups. Quality of life was assessed using MSQOL-54 Persian version at the beginning and at the end of the study.

RESULTS:

After 3 months, the vitamin D group had a significant difference in mental health composite with placebo group, 62.41 ± 13.99 vs. 60.99 ± 17.99 (p-value = 0.041). Change in health was 75.74 ± 25.73 and 70.59 ± 26.45 in vitamin D and placebo group, respectively (p-value = 0.036).

CONCLUSIONS:

Mental QOL improved significantly after taking high dose vitamin D for 3 months in vitamin D group relative to placebo.

KEYWORDS:

Mental health; Multiple sclerosis; Physical health; Quality of life; Vitamin D

PMID:
27597724
DOI:
10.1080/01616412.2016.1227913
[Indexed for MEDLINE]

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