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Vet Dermatol. 2016 Dec;27(6):464-e123. doi: 10.1111/vde.12374. Epub 2016 Sep 5.

A split-body, randomized, blinded study to evaluate the efficacy of a topical spray composed of essential oils and essential fatty acids from plant extracts with antimicrobial properties.

Author information

1
Dermatology Referral Service, Clinique Vétérinaire, 6 rue mare pavée, 35510, Rennes-Cesson, France.
2
Laboratoire de Dermo-Cosmétique Animale (LDCA), ZA Le Causse, 81100, Castres, France.

Abstract

BACKGROUND:

Bacterial pyoderma is a frequent presentation in dogs. Despite the widespread availability of effective systemic and topical antimicrobial products, good clinical practice currently recommends avoidance of long-term use to mitigate the development of bacterial resistance.

HYPOTHESIS/OBJECTIVES:

To evaluate the speed of resolution of clinical signs of bacterial pyoderma in dogs treated with a systemic antimicrobial agent with or without the use of an adjunctive spray with antimicrobial properties.

ANIMALS:

Twelve dogs with superficial bacterial pyoderma.

METHODS:

In this controlled and blinded study, all dogs were treated with oral cefalexin and a topical spray (PYOClean Spray) for 4 weeks. The spray was applied to one half of each dog's body, whereas a placebo spray was applied to the other half.

RESULTS:

Twelve dogs completed the study. Mean clinical scores were significantly reduced on spray-treated sites, for test product and placebo (respectively), by 47% and 34% at Week 1, 83% and 60% at Week 2, 95% and 82% at Week 3, and 100% and 96% at Week 4. Fifty percent of treated sites were considered clinically and cytologically cured at Week 2, 83% at Week 3, and 100% at Week 4 compared to 8%, 50% and 83% for the placebo sites, respectively.

CONCLUSIONS AND CLINICAL IMPORTANCE:

These results demonstrate that use of a topical spray which contains plant-derived essential oils and fatty acids, and compounds with antimicrobial properties (Manuka oil and N-acetyl cysteine) may help to speed resolution of pyoderma and may allow for shorter antimicrobial treatment time.

PMID:
27597636
DOI:
10.1111/vde.12374
[Indexed for MEDLINE]

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