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Curr Opin Virol. 2016 Dec;21:75-80. doi: 10.1016/j.coviro.2016.08.003. Epub 2016 Sep 3.

In vivo tissue-tropism of adeno-associated viral vectors.

Author information

1
Division of Cellular and Molecular Therapy, Department of Pediatrics, Powell Gene Therapy Center, University of Florida College of Medicine, 2033 Mowry Road, Gainesville, FL 32611, United States; Department of Molecular Genetics & Microbiology, Powell Gene Therapy Center, University of Florida College of Medicine, 2033 Mowry Road, Gainesville, FL 32611, United States. Electronic address: aruns@peds.ufl.edu.

Abstract

In this review, a brief account of the historical perspective of the discovery of the first cellular receptor and co-receptor of the prototype adeno-associated virus serotype 2 (AAV2) will be presented. The Subsequent discovery of a number of AAV serotypes, and attempts to identify the cellular receptors and co-receptors for these serotype vectors has had significant implications in their use in human gene therapy. As additional AAV serotypes are discovered and isolated, a detailed understanding of their tropism is certainly likely to play a key role in all future studies, both basic science as well as clinical.

PMID:
27596608
PMCID:
PMC5138125
DOI:
10.1016/j.coviro.2016.08.003
[Indexed for MEDLINE]
Free PMC Article

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