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Pharmacol Ther. 2017 Mar;171:65-74. doi: 10.1016/j.pharmthera.2016.09.005. Epub 2016 Sep 2.

Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.

Author information

1
BHF Center for Vascular Regeneration and MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, UK; Department of Trauma and Orthopaedic Surgery, The University of Edinburgh, Edinburgh, UK.
2
BHF Center for Vascular Regeneration and MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
3
Reseach Laboratory of Electronics and Department of Biological Engineering, Massachusetts Institute of Technology, Boston, MA, USA.
4
Orthopedic Hospital Research Center, University of California, Los Angeles, CA, USA.
5
Division of Cardiology, Department of Medicine & Molecular Cell and Developmental Biology, and Eli and Edythe Broad Institute of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, CA, USA. Electronic address: adeb@mednet.ucla.edu.
6
MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. Electronic address: Neil.Henderson@ed.ac.uk.

Abstract

Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognized to fulfill an increasing number of functions in normal tissue homeostasis, including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states, including fibrosis, heterotopic ossication and calcification, atherosclerosis, and tumor angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.

KEYWORDS:

Heart; MSC; Mesenchymal stem cell; Muscle; PSC; Perivascular stem cell

PMID:
27595928
PMCID:
PMC5726267
DOI:
10.1016/j.pharmthera.2016.09.005
[Indexed for MEDLINE]
Free PMC Article

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