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Am Heart J. 2016 Sep;179:151-6. doi: 10.1016/j.ahj.2016.07.001. Epub 2016 Jul 12.

Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention.

Author information

1
Inova Heart and Vascular Institute, Falls Church, VA. Electronic address: Christopher.Defilippi@inova.org.
2
Department of Medicine, University of Texas Southwestern, Dallas, TX.
3
Department of Medicine, University of Pittsburgh, Pittsburgh, PA.
4
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD.
5
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD.
6
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL.
7
Department of Preventive Medicine, Louisiana State University, Baton Rouge, LA.
8
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
9
Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC.
10
Department of Medicine, Stanford University, Palo Alto, CA.
11
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.

Abstract

BACKGROUND:

In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay.

METHODS:

Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50% increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire.

RESULTS:

Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range -0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range -1.10 to 1.93) (P=.02). The proportion with a>50% increase in hs-cTnT was larger in the control group than in the PA group (9.3% vs 5.1%), but this difference was not statistically significant (P=.16).

CONCLUSIONS:

Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.

PMID:
27595690
DOI:
10.1016/j.ahj.2016.07.001
[Indexed for MEDLINE]

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