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Med Arch. 2016 Jun;70(3):172-6. doi: 10.5455/medarh.2016.70.172-176. Epub 2016 May 31.

In Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2.

Author information

1
Department of Pharmacology, Medical Faculty, Hang Tuah University, Surabaya, East Java, Indonesia. Address: Jl. Gadung No. 1, Surabaya, East Java, Indonesia.

Abstract

INTRODUCTION:

The enzyme cyclooxygenase (COX) is an enzyme that catalyzes the formation of one of the mediators of inflammation, the prostaglandins. Inhibition of COX allegedly can improve inflammation-induced pathological conditions.

AIM:

The purpose of the present study was to evaluate the potential of Sargassum sp. components, Fucoidan and alginate, as COX inhibitors.

MATERIAL AND METHODS:

The study was conducted by means of a computational (in silico) method. It was performed in two main stages, the docking between COX-1 and COX-2 with Fucoidan, alginate and aspirin (for comparison) and the analysis of the amount of interactions formed and the residues directly involved in the process of interaction.

RESULTS:

Our results showed that both Fucoidan and alginate had an excellent potential as inhibitors of COX-1 and COX-2. Fucoidan had a better potential as an inhibitor of COX than alginate. COX inhibition was expected to provide a more favorable effect on inflammation-related pathological conditions.

CONCLUSION:

The active compounds Fucoidan and alginate derived from Sargassum sp. were suspected to possess a good potential as inhibitors of COX-1 and COX-2.

KEYWORDS:

COX-1; COX-2; Fucoidan; Sargassum sp; alginate

PMID:
27594740
PMCID:
PMC5010064
DOI:
10.5455/medarh.2016.70.172-176
[Indexed for MEDLINE]
Free PMC Article

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