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Acta Neurol Scand. 2016 Oct;134(4):292-9. doi: 10.1111/ane.12543. Epub 2015 Dec 21.

Soil heavy metals are associated with the distribution of multiple sclerosis in Isfahan, Iran.

Author information

1
Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
2
Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Isfahan University of Medical Sciences, Isfahan, Iran.
3
Department of Geochemistry, Faculty of Earth Sciences, Kharazmi University, Tehran, Iran.
4
Isfahan Research Committee of Multiple Sclerosis (IRCOMS), Isfahan University of Medical Sciences, Isfahan, Iran. reyhaneh.kiani89@gmail.com.
5
Department of Geochemistry, Faculty of Earth Sciences, Kharazmi University, Tehran, Iran. reyhaneh.kiani89@gmail.com.
6
Medical Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
7
Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran.
8
University of Oxford, Oxford, UK.
9
Evidera, London, UK.
10
Department of Neuropathology, University Medical Center, Georg August University, Göttingen, Germany.

Abstract

BACKGROUND:

Few epidemiological studies have explored the effects of soil pollution on multiple sclerosis (MS) risk in Asia.

METHOD:

Based on catchment areas, Isfahan province is divided into five regions (Central, North, East, West, and South), and Soil sampling performed in catchment area with the highest range of MS prevalence and incidence. Samples were analyzed for cobalt (Co), lead (Pb), cadmium (Cd), copper (Cu), zinc (Zn), and absorbable forms of Pb, Cd, and Co. Linear regression is used to examine the association of soil heavy metals with prevalence of MS in central part of Isfahan province.

RESULT:

Multiple sclerosis prevalence ranged from 5.62 to 156.65 in different townships. Based on regression analysis, in case of considering fixed amounts for the rest of elements, a one (SD) increase of absorbable Pb and absorbable Cd are associated with 0.385 (SD) (P < 0.0001) increase and 0.209 (SD) (P < 0.007) decrease in MS prevalence, respectively.

CONCLUSION:

This study documented a significant association between exposure to absorbable Pb and Cd in soil with prevalence of MS in Isfahan. Further work is warranted to confirm this association and if validated, to understand the mechanisms behind the association.

KEYWORDS:

Iran; Isfahan; multiple sclerosis; prevalence; soil heavy metal

PMID:
27592843
DOI:
10.1111/ane.12543
[Indexed for MEDLINE]

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