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Clin Chim Acta. 2016 Nov 1;462:55-59. doi: 10.1016/j.cca.2016.08.022. Epub 2016 Sep 1.

Physical activity and albuminuria were associated with painful diabetic polyneuropathy in type 2 diabetes in an ethnic Chinese population.

Author information

1
Divisions of Internal Medicine, Sinying Hospital, Tainan 73042, Taiwan, ROC.
2
Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC; Department of Public Health, College of Public Health, China Medical University, Taichung 40402, Taiwan, ROC; Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC.
3
Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC.
4
Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC; School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, ROC.
5
Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC; Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei 10617, Taiwan, ROC.
6
Institute of Biostatistics, China Medical University, Taichung 40402, Taiwan, ROC.
7
Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC; School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, ROC; College of Medicine, National Defense Medical Center, Taipei 11490, Taiwan, ROC.
8
Divisions of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC; School of Medicine, National Yang Ming University, Taipei 11221, Taiwan, ROC; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROC. Electronic address: sylin@vghtc.gov.tw.

Abstract

BACKGROUND:

Diabetic neuropathy is a common complication in patients with type 2 diabetes. However, the prevalence of painful diabetic polyneuropathy (PDPN) have been less studied. We examined the prevalence and risk factors of PDPN in outpatients with type 2 diabetes in an ethnic Chinese population.

METHODS:

This retrospective study enrolled 2358 outpatients with type 2 diabetes who had completed the Douleur Neuropathique en 4 Questions (DN4) questionnaire from January 2013 to October 2013. Patients with a total score ≥4 were defined as having PDPN.

RESULTS:

In all, 179 patients were diagnosed as having PDPN with a score of 4.49 on the DN4 questionnaire, compared with 0.66 for patients without PDPN. After adjusting the possible confounding factors, the risk of painful neuropathy was increased in the group without physical activity (Odds ratio 3.38, 95% CI 1.54-9.79), and in the group with macroalbuminuria (Odds ratio 2.31, 95% CI 1.44-3.73). Besides, there was a joint effect of macroalbuminuria and no physical activity habit on PDPN risk.

CONCLUSIONS:

The prevalence of PDPN was 7.6% among our outpatients with type 2 diabetes. Less physical activity and albuminuria, respectively, increased the risk of PDPN and had a joint effect.

KEYWORDS:

Albuminuria; Diabetic neuropathy; Ethnic Chinese; Painful diabetic polyneuropathy; Physical activity

PMID:
27592367
DOI:
10.1016/j.cca.2016.08.022
[Indexed for MEDLINE]

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