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Acta Neurochir (Wien). 2016 Nov;158(11):2127-2134. Epub 2016 Sep 2.

Gender-specific growth dynamics of neurofibromatosis type-2-related tumors of the central nervous system.

Author information

1
Department of Neurosurgery, HELIOS Klinikum Erfurt, Nordhäuser Str. 74, 99089, Erfurt, Germany. anna.lawsonmclean@gmail.com.
2
Department of Neurosurgery, HELIOS Klinikum Erfurt, Nordhäuser Str. 74, 99089, Erfurt, Germany.

Abstract

BACKGROUND:

To date, few studies have been published about the growth dynamics of tumors associated with neurofibromatosis type-2 (NF2), none of which evaluated gender-specific differences. Our aim was to compare radiographic data of female and male patients with NF2.

METHODS:

MR images of 40 patients (20 female, 20 male) from the regional NF2 referral center were included in this analysis. Tumor sizes were determined by semi-automated volumetric measurement. Intracranial tumors were measured on post-contrast T1-weighted MRI datasets and volumes of intramedullary spinal tumors were determined from sagittal T2-weighted MRI datasets.

RESULTS:

The median follow-up time was 91 months (range, 16-199 months) per patient. Intracranial tumors: On average, female patients had 13.4 neoplasms, while male patients had 6.75 (p = 0.042). The overall median time to tumor progression of ≥20 % was 20 months for females and 18 months for males. Tumors of the cerebellopontine angle (CPA) that had undergone previous surgery had shorter progression-free intervals in females than in males (16 and 24 months, respectively; p = 0.012). The median 1-year growth rate was 17.5 ± 44.6 % in females compared to 12.5 ± 44.9 % in males (p = 0.625). Intramedullary spinal tumors: On average, females had 2.05 tumors and males had 1.75 tumors (p = 0.721). Median time to tumor progression was 21 months in females and 44 months in males (p = 0.204). After 2 years, the median growth rate was 24.4 ± 56.8 % in female and 13.5 ± 40.4 % in male patients (p = 0.813).

CONCLUSIONS:

The radiographic data in this study suggest that female patients are affected by a greater number of tumors than male patients and that post-surgery tumors of the CPA grow faster in females than in males.

KEYWORDS:

Gender; Growth dynamics; Magnetic resonance imaging; Neurofibromatosis

PMID:
27590907
DOI:
10.1007/s00701-016-2927-9
[Indexed for MEDLINE]

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