National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report

Biol Blood Marrow Transplant. 2017 Feb;23(2):201-210. doi: 10.1016/j.bbmt.2016.08.019. Epub 2016 Aug 30.

Abstract

A number of studies have shown that autologous and allogeneic hematopoietic cell transplantation (HCT) contribute to an increased incidence of cardiovascular disease (CVD) and worsening of cardiovascular risk factors that could contribute to further CVD over time. These observations, combined with a notable increase in the number of survivors after HCT in recent years, highlight the need for studies aimed at modifying risk or preventing these outcomes by changing specific approaches and/or post-HCT interventions. To address these issues, the National Heart, Lung and Blood Institute and National Cancer Institute co-sponsored an international initiative on late effects after HCT. This report summarizes the major gaps in knowledge along with detailed recommendations regarding study priorities from the Cardiovascular Disease and Associated Risk Factors Committee, a multidisciplinary panel of international experts. The committee calls for specific studies aimed at understanding and preventing arterial disease and cardiac dysfunction (heart failure, valvular disease, and arrhythmias), as well as decreasing cardiovascular risk factors (hypertension, hyperglycemia, dyslipidemia, and sarcopenic obesity) after HCT.

Keywords: Cardiovascular disease; Cardiovascular risk factors; Chronic disease; Hematopoietic cell transplantation; Late effects; National Institutes of Health consensus; Survivorship.

Publication types

  • Consensus Development Conference, NIH

MeSH terms

  • Adult
  • Allografts
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / therapy
  • Child
  • Dyslipidemias / epidemiology
  • Dyslipidemias / etiology
  • Dyslipidemias / therapy
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Hyperglycemia / epidemiology
  • Hyperglycemia / etiology
  • Hyperglycemia / therapy
  • Obesity / epidemiology
  • Obesity / etiology
  • Obesity / therapy
  • Research
  • Retrospective Studies
  • Risk Factors
  • Sarcopenia / epidemiology
  • Sarcopenia / etiology
  • Sarcopenia / therapy
  • Survivors / statistics & numerical data
  • Transplantation Conditioning / adverse effects