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J Stud Alcohol Drugs. 2016 Sep;77(5):676-80.

Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.

Author information

1
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri arpana@wustl.edu.
2
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana edenberg@iu.edu.
3
Department of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, New Haven, Connecticut.
4
Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut joel.gelernter@yale.edu.

Abstract

Meta-analyses of genome-wide association study data have begun to lead to promising new discoveries for behavioral and psychiatrically relevant phenotypes (e.g., schizophrenia, educational attainment). We outline how this methodology can similarly lead to novel discoveries in genomic studies of substance use disorders, and discuss challenges that will need to be overcome to accomplish this goal. We illustrate our approach with the work of the newly established Substance Use Disorders workgroup of the Psychiatric Genomics Consortium.

PMID:
27588522
PMCID:
PMC5015465
DOI:
10.15288/jsad.2016.77.676
[Indexed for MEDLINE]
Free PMC Article

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